Effects of Tetramethylpyrazine on TXA_2 and PGl_2in Congenital Heart Diseases with Pulmonary Hypertension Patients during Cardio-Pulmonary Bypass  

作　　者：黄瑞健 瘳崇先 陈道中 陈为民 翁钦永 

出　　处：《Chinese Journal of Integrative Medicine》1998年第4期266-266,共1页中国结合医学杂志（英文版）

摘　　要：Objective: To study protective effects of Tetramethylpyrazine (TMP) on the imbalance of TXA2/PGI2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) patients with pulmonary hypertension (PH).Methods: The 30 patients suffered from noncyanotic CHD-PH were randomly divided into control group (n = 15) and treatment group (n = 15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected after anesthesia induction, 15 min after CPB, 5 min after release of the aortic cross-clamp, 20 min, 6 hrs and 24 hrs after CPB, TXA2 and PGI2 were measured. Results: There was significant difference between treatment group and control group except before operation and 24 hrs after CPB. Conclusion: The imbalance of TXA2 and PGI2 in patients with CHD-PH during CPB could be corrected by TMP.Original article on CJIM(Chin) 1998; 18(6): 333Objective: To study protective effects of Tetramethylpyrazine (TMP) on the imbalance of TXA2/PGI2 during cardiopulmomary bypass (CPB) in congenital heart disease (CHD) patients with pulmonary hypertension (PH).Methods: The 30 patients suffered from noncyanotic CHD-PH were randomly divided into control group (n = 15) and treatment group (n = 15). 3 mg/kg of TMP was dripped intravenously after anesthesia and 1 mg/kg of TMP was infused into oxygenator after CPB individually. Blood samples were collected after anesthesia induction, 15 min after CPB, 5 min after release of the aortic cross-clamp, 20 min, 6 hrs and 24 hrs after CPB, TXA2 and PGI2 were measured. Results: There was significant difference between treatment group and control group except before operation and 24 hrs after CPB. Conclusion: The imbalance of TXA2 and PGI2 in patients with CHD-PH during CPB could be corrected by TMP.Original article on CJIM(Chin) 1998; 18(6): 333

分 类 号：R541[医药卫生—心血管疾病]