EXPERIMENTAL STUDY OF THE BIOCHEMICAL REMODELLING OF VENTRICULAR COLLAGEN FOLLOWING MYOCARDIAL INFARCTION IN RATS TREATED WITH CAPTOPRIL  

作　　者：黄英 雷立权 刘秉慈 高广道 孙晓明 

出　　处：《Journal of Pharmaceutical Analysis》1998年第2期103-108,共6页药物分析学报（英文版）

摘　　要：The present study is to determine the effects of captoprll treatment on myocyte hypertropay. collagen concentration, the total collagen content, type Ⅰ and type,Ⅲ collaged Protein ratio[Ⅰ / Ⅲ (p)] and their mRNA ratio [Ⅰ / Ⅲ (R)]3 In non-infarcted area(NⅡA), infarcted area(ⅡA) ofleft ventricle (LV) and right ventricle(RV) rollowing myocardial inrarction (MⅡ) in rats. The results showed: ①Captopril treatment can prevent myocyte hypertrophy in CⅡA and RV, but its effectson biochemical remodelling or collaged in CⅡA, RV and ⅡA were different. In NⅡA, the total collagencontent, collagen concentration and the Ⅰ /Ⅲ (P) were returned to their control values respectively.However, captopril treatment only decreased the total collagen content in RV and had no significanteffects on the total collagen content, collagen concentration and Ⅰ /Ⅲ (P) in ⅡA; ② The changes ofⅠ /Ⅲ (R) In CⅡA, ⅡA aam RV showed similar patterns to their Ⅰ /Ⅲ (P) respctily The resultssuggest:① The adulatory mechanism of collageu remodelling may be different in various hypertrophy models. Accompanied'by the regression of myocyte hypertrophy, the changes of collagen matrixmay not occur concurrently; ② The efects of captopril treatment on collagen remodelling may bedue to its decreasing angiotensiu Ⅱ level, and then influencing collagen synthesis of cardiac fibroblast on the level of gene expression.The present study is to determine the effects of captoprll treatment on myocyte hypertropay. collagen concentration, the total collagen content, type Ⅰ and type,Ⅲ collaged Protein ratio[Ⅰ / Ⅲ (p)] and their mRNA ratio [Ⅰ / Ⅲ (R)]3 In non-infarcted area(NⅡA), infarcted area(ⅡA) ofleft ventricle (LV) and right ventricle(RV) rollowing myocardial inrarction (MⅡ) in rats. The results showed: ①Captopril treatment can prevent myocyte hypertrophy in CⅡA and RV, but its effectson biochemical remodelling or collaged in CⅡA, RV and ⅡA were different. In NⅡA, the total collagencontent, collagen concentration and the Ⅰ /Ⅲ (P) were returned to their control values respectively.However, captopril treatment only decreased the total collagen content in RV and had no significanteffects on the total collagen content, collagen concentration and Ⅰ /Ⅲ (P) in ⅡA; ② The changes ofⅠ /Ⅲ (R) In CⅡA, ⅡA aam RV showed similar patterns to their Ⅰ /Ⅲ (P) respctily The resultssuggest:① The adulatory mechanism of collageu remodelling may be different in various hypertrophy models. Accompanied'by the regression of myocyte hypertrophy, the changes of collagen matrixmay not occur concurrently; ② The efects of captopril treatment on collagen remodelling may bedue to its decreasing angiotensiu Ⅱ level, and then influencing collagen synthesis of cardiac fibroblast on the level of gene expression.

关 键 词：COLLAGEN biochemical remodelling myotyte hypertropky CAPTOPRIL myocardial infarction 

分 类 号：R542.22[医药卫生—心血管疾病]