Chiral Separation of Esmolol and Terazosin by Cyclodextrinmodified Capillary Zone Electrophoresis  

作　　者：Yi Yang Dong Xue Qin REN Ai Jin HUANG Yi Liang SUN Zeng Pei SUN(Department of Chendstry, Peking University, Beijing 10087)(National Institute for the Control of Pharmaceutical and Biological Products, Beijing 100050) 

出　　处：《Chinese Chemical Letters》1998年第6期565-568,共4页中国化学快报（英文版）

摘　　要：Cyclodextrin-modified CZE was applied to the chiral separation of two basic drugs, i.e., esmolol and terazosin. Selector screening and concentration optimization experiments were performed. Resolution 3.1 for esmolol, 1.2 for terazosin were achieved when using 60 mmol/L gamma-CD and 60 mmoL/L DM-P-CD, respectively, in 50 mmol/L pH 2.5 sodium phosphate buffer.Cyclodextrin-modified CZE was applied to the chiral separation of two basic drugs, i.e., esmolol and terazosin. Selector screening and concentration optimization experiments were performed. Resolution 3.1 for esmolol, 1.2 for terazosin were achieved when using 60 mmol/L gamma-CD and 60 mmoL/L DM-P-CD, respectively, in 50 mmol/L pH 2.5 sodium phosphate buffer.

关 键 词：capillary zone electrophoresis chiral separation CYCLODEXTRIN ESMOLOL TERAZOSIN 

分 类 号：O657.8[理学—分析化学]