Structure Based Library Approach to Photosynthesis Inhibitors:The Solid Phase Synthesis of Hydro-Uracils and Thiouracils  

作　　者：Yu, AM Yang, HZ Zhang, ZP 

机构地区：[1]Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China [2]Nankai Univ, State Key Lab Funct Polymer Mat Adsorpt & Separat, Tianjin 300071, Peoples R China

出　　处：《Chinese Chemical Letters》1998年第2期139-142,共4页中国化学快报（英文版）

摘　　要：A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.A general method for the solid phase synthesis of hydro-uracils and thiouracils is described. Resino ester 2 reacts with various primary amines to give secondary amines 3, which are converted to the resino ureas (thioureas) 4 by treatment with isocyanates (isothiocyanates). Preparation of the hydro-uracils and thiouracils 5 is achieved by acidic cyclization-cleavage from the resin. The synthesis is designed to be amenable for structure based library approach to photosystem II D1 protein inhibitors.

关 键 词：solid phase synthesis hydro-uracils and thiouracils photosynthesis inhibitors 

分 类 号：O644[理学—物理化学]