Synthesis of the C_(11-16)+C_(27) Segment of Epothilone A  

作　　者：Zhi Yu LIU Rui Fang WANG Yue Hai SHEN (Shanghai Institute of Organic Chemistry Chinese Academy of Sciences,354 Fenglin Lu. Shanghai 200032) 

出　　处：《Chinese Chemical Letters》1998年第1期35-38,共4页中国化学快报（英文版）

摘　　要：A chiral synthesis of the C11-16+C27 segment of epomilone A is described using inexpensive L-(-)-malic acid as staring materinal and using Sharpless asymmetric epoxidahon for introduction of the desired 12, 13 epoxide.A chiral synthesis of the C11-16+C27 segment of epomilone A is described using inexpensive L-(-)-malic acid as staring materinal and using Sharpless asymmetric epoxidahon for introduction of the desired 12, 13 epoxide.

关 键 词：Epothilone A L-(-)-malic acid asymmetric epoxidation 

分 类 号：O613[理学—无机化学]