细胞自噬在病毒感染与免疫调节中的作用机制  

Regulation of Viral Infection and Immune Response by Autophagy

作　　者：王凯[1] 郑洋[1] 邢雅玲[1] 陈晓娟[1] 陈忠斌[1] 

机构地区：[1]军事医学科学院放射与辐射医学研究所,北京100850

出　　处：《中国生物化学与分子生物学报》2011年第11期987-992,共6页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金(No.30870536;No.30972761;No.81172799);国家科技重大专项(No.2008ZX10004-015);北京市自然科学基金(No.7092075);教育部留学回国人员科研启动基金(2009)资助~~

摘　　要：细胞自噬(autophagy)是一种主要由溶酶体介导的降解通路,作为细胞维持内环境稳态的一种保护性机制,不仅通过将长寿命蛋白和衰老细胞器降解为小肽或氨基酸为细胞提供再生资源,而且也可作为防御机制抵抗病原微生物感染和寄生.自噬缺失与许多疾病如癌症、心血管疾病等的发生关系密切,在机体生理、病理过程中发挥重要作用.本文拟就细胞自噬与病毒感染、机体免疫的关系加以综述,以期为研究细胞自噬的发生、参与机体免疫、发挥抗病毒感染作用及其分子机制提供参考,也为进一步研究抗病毒治疗的靶标提供新思路.As a protective mechanism to sustain cellular homeostatic,cellular autophagy is the degradation pathway mediated by lysosome.Autophagy provides recycle resource for cell by degradating long-live protein and senile cell organelle to small peptide or amino acid.In the mean time,atuophagy can repress the pathogenic infection and parasitization.It was demonstrated that the deficiency of the autophagy was related to many diseases including cancer,cardiovascular disease,implying the improtance of the autophagy in the physiological and pathological process.In this review,we summarized the relationship between the autophagy and the immunity including the innate and the adaptive immune response,and described the interaction between the autophagy and human virus infection.Further studying the molecular mechanism of autophagy will contribute to understanding the cellular autophagy development and the autophagy pathway involving in regulation of the immunity to initiate the antiviral infection.Also,it can offer the new idea to find the targets of antiviral therapy.

关 键 词：细胞自噬 天然免疫 适应性免疫 病毒感染 

分 类 号：Q27[生物学—细胞生物学]