Design,synthesis and biological activity of novel herbicides targeted ALS(Ⅻ)--Quantitative structure-activity relationships of herbicidal l,2,4-triazolo[l,5-a]pyrimidine-2-sulfonanilides  

作　　者：杨光富 刘华银 杨秀凤 杨华铮 

机构地区：[1]Institute of Organic Synthesis,Central China Normal University,Wuhan,Hubei 430079,China [2]State Key Laboratory and Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,China

出　　处：《Chinese Journal of Chemistry》1998年第6期521-527,共7页中国化学（英文版）

基　　金：Project (No. 29472056) supported by the National Natural Science Foundation of China

摘　　要： The herbicidal activities of a series of 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides containing various substituents on the benzene ring were quantitatively analyzed with physicochemi-cal parameters by using Hansch-Fujita method.Variations in the activity were parabolically related to electronic parameters with the optimum pKavalue being about 6.93.The hydrophobic factor in addition to the electronic property seemed to have important effect on the activity.<正> The herbicidal activities of a series of 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides containing various substituents on the benzene ring were quantitatively analyzed with physicochemi-cal parameters by using Hansch-Fujita method.Variations in the activity were parabolically related to electronic parameters with the optimum pKavalue being about 6.93.The hydrophobic factor in addition to the electronic property seemed to have important effect on the activity.

关 键 词：QSAR ALS inhibitors 1 2 4-triazolo[1 5-a]pyrimidine-2-sulfonanilides 

分 类 号：TQ457[化学工程—农药化工]