Highly efficient catalysts derived from planar chiral ferrocenes for asymmetric transfer hydrogenation of ketones  

作　　者：杜向东 戴立信 侯雪龙 夏立钧 唐明华 

机构地区：[1]Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 300032, China

出　　处：《Chinese Journal of Chemistry》1998年第1期90-93,共4页中国化学（英文版）

基　　金：Project (29772046) supported by the National Natural Science Foundation of China and Chinese Academy of Scienses.

摘　　要：Planar chiral ferrocenes 1 and its diastereoisomer 2 were found to be good lig-ands for. the ruthenium catalyzed asymmetric transfer hydrogenation of ketones with i-PrOH as hydrogen source under refluxing in the presence of sodium hydroxide. The results showed that the absolute configuration of alcohol seemed to be governed by the central chirality in the oxazoline ring instead of the planar chirality. At a ratio of 1:2 for Ru:ligand, 3000:1 S/C and >100,000/h?1 TOF were observed for acetophenone. For propiophenone 99% yield and 85% e.e. were obtained.Planar chiral ferrocenes 1 and its diastereoisomer 2 were found to be good lig-ands for. the ruthenium catalyzed asymmetric transfer hydrogenation of ketones with i-PrOH as hydrogen source under refluxing in the presence of sodium hydroxide. The results showed that the absolute configuration of alcohol seemed to be governed by the central chirality in the oxazoline ring instead of the planar chirality. At a ratio of 1:2 for Ru:ligand, 3000:1 S/C and >100,000/h?1 TOF were observed for acetophenone. For propiophenone 99% yield and 85% e.e. were obtained.

关 键 词：Asymmetric transfer hydrogenation planar chiral phosphinoferrocenyloxazoline ruthenium complex 

分 类 号：O643.3[理学—物理化学]