血浆S-100B蛋白测定在外伤性颅内血肿诊疗中的临床意义  

Clinical significance of serum S-100B protein in diagnosing and treating traumatic intracranial haematoma

作　　者：胡殿雷[1] 李伯安[1] 王余军[1] 韩松[2] 

机构地区：[1]徐州医学院附属第三医院神经外科,江苏221003 [2]徐州医学院附属第三医院核医学科,江苏221003

出　　处：《创伤外科杂志》2011年第6期494-496,共3页Journal of Traumatic Surgery

基　　金：江苏省徐州市科技局基金资助项目(X2001056);获徐州市科技进步三等奖(2006064)

摘　　要：目的探讨血浆S-100B蛋白在不同类型外伤性颅内血肿的诊断、分型、指导治疗中的临床价值。方法颅内血肿116例,根据头颅CT分为硬膜外血肿(52例)、硬膜下血肿(32例)、脑内血肿(32例)三组,伤后早期(6小时内)抽取血浆测定S-100B蛋白含量,伤后每24小时送检1次,动态测定(3～7天)。三组两两比较。结果脑内血肿患者伤后6小时内及达到峰值时S-100B蛋白含量均高于单纯硬膜外、硬膜下血肿组,差异显著。硬膜下血肿组与硬膜外血肿组比较有差异。结论血浆S-100B蛋白在颅内血肿的诊断分型及预后判断中具有可靠的应用价值。Objective To investigate the value of S-100B protein as a biology marker in diagnosing,classifying and treating traumatic intracranial haematoma.Methods Totally 116 cases of traumatic intracranial haematoma were included in this study,and divided into three groups including epidural hematoma group（52 cases）,subdural hematoma group（32 cases）,intracerebral hematoma group（32 cases） based on head CT.Venous blood samples for S-100B protein were obtained as soon as possible after admission and every 24 hours during the 3-7 days after injury.Three groups were compared with each other.Results Patients with intracerebral hematoma had significantly higher serum S-100B values compared with other groups,and the serum S-100B value in the subdural hematoma group was different with that in the epidural hematoma group.Conclusion S-100B protein has reliable value in the diagnosis and prognosis of traumatic intracranial haematoma.

关 键 词：颅内血肿 S-100B蛋白 预后 

分 类 号：R446.62[医药卫生—诊断学] R651.1[医药卫生—临床医学]