血清耐热碱性磷酸酶的测定在正常孕妇与高危孕妇中的应用  

Clinical application of monitoring serum heat-stable alkaline phosphatase in normal pregnancy and high-risk preguancy

作　　者：范丽娟 赵莲 

机构地区：[1]同仁医院妇产科,北京市100730

出　　处：《中国全科医学》1998年第1期11-13,共3页Chinese General Practice

摘　　要：探讨血清耐热碱性磷酸酶（HSAP）在正常孕妇与高危孕妇中的应用。方法采用放射免疫的方法对153例孕妇进行血清耐热碱性磷酸酶的测定，同时均行胎心监护。结果孕周＜41周与41周≤孕周＜42周的正常孕妇的血清HSAP水平无差异，但后者的平均值略低于前者，妊娠高血压综合症、胎儿宫内发育迟缓（IUGR）、合并胎盘钙化的胎儿宫内窘迫血清HSAP降低，单纯服心羊水异常的胎儿宫内窘迫患者血清HSAP与正常孕妇无差异，服监监测胎盘功能不似血清HSAP直接，阳性率低。结论测定血清HSAP可以反映胎盘功能，对高危妊娠的监测及胞儿领后的估计有一定临床参考价值。Objective To investigate the application of serum heat-stable alkaline phosphatase inpregnancy. Methods Serum heat-stable alkaline phosphatase (HSAP) level in 153 cases of pregnancywas measured by radioimmunoassay. Results In the pregnant women at 41 week gestation, the HSAPlevels were similar to those at ≥ 41 t＜42 week gestation. The HSAP in patients with pregnancy induced hypertension, intrauterine fetal growth retardation and placental abruption were low . In thosecases of fetal distress accompanied by placenta calcification, the HSAP were also at low level. But in patients whose fetal distress was only diagnosed by abnormality of fetal heart rate and amniotic fluid, theHSAP were not significant with those of normal pregnancy. Conclusion Monitoring the serum HSAPcan reflect the placental funciton, which can play an important role in the evaluation of the high-riskpregnancy and fetal prognosis.

关 键 词：耐热碱性磷酸酶 妊娠 胎盘 

分 类 号：R446.1[医药卫生—诊断学]