早期肠内营养对创伤后肠粘膜屏障功能的影响  

EFFECTS OF EARLY ENTERAL DIETOTHERAPY ON BARRIER ACTION OF INTESTINAL MUCOSA AFTER BURN

作　　者：曹卫[1] 邵洪[2] 尹致良[2] 田伏洲[2] 刘晓波[2] 李小军[2] 

机构地区：[1]成都军区总医院药学部,成都610083 [2]成都军区总医院普外中心

出　　处：《西南国防医药》1998年第6期327-330,共4页Medical Journal of National Defending Forces in Southwest China

摘　　要：为进一步探讨严重创伤早期肠粘膜屏障功能的改变及肠道营养的作用,作者设计了一个新的动物模型,即在肠系膜下静脉、门静脉和中心静脉插入导管分别获取不同区域的血标本进行细菌培养和测定内毒素等指标,使研究成为一个既相对独立又相互关联的整体。避免了既往模型向肠道灌饲活菌使肠粘膜遭受非创伤原因损害的人为影响因素。致伤(体表烧伤Ⅱ°30％)后动物随机分为两组:早期饲养EF组(伤后2h开始饲养)和延迟饲养DF组(伤后第4d开始饲养)。结果表明,早期肠内营养能明显刺激伤后肠粘膜细胞的增殖与修复,能有效地增强肠粘膜屏障功能,明显减少肠道细菌及内毒素的移位。肠内食物对于维护肠粘膜的结构和功能以及修复受损的肠粘膜细胞是至关重要的。Prupose: to study further the changes of barrier action of intestinal mucosa after severe burn and the effects of early enteral dietotherapy. Method: A new model was estabolished that blood samples were taken from three ducts, respectively, which had been intubated into inferior meseneric vein, portal vein and central vein of pigs. Then the bacterial culture were made and endotoxin was examined. After 12 animals were burned(III, 30%), they were divided randomly into early feed group which would be fed at post -burn 2 h and delay feed group which be fed on the post - burn 4th day. Result: Early enteral dietotherapy could promote mucous cell multiplication and restoration, which would increase barrier action of intestinal mucosa and decrease bactera and endotoxin in the intestine. Thus it is confirmed that early enteral dietotherapy is very important to the intestinal function and restoration of injured intestinal mucosa cells.

关 键 词：烧伤 肠粘膜 肠饲 肠源性感染 

分 类 号：R459.3[医药卫生—治疗学]