尿视黄醇结合蛋白与肾小管间质受损的相关性研究  

Correlation studies between urinary retinol binding protein and renal tubular damage

作　　者：夏运成[1,2] 彭灿辉[2] 屈申[1] 刘伏友[2] 彭佑铭[2] 

机构地区：[1]华中科技大学同济医学院分子生物与生物化学系,武汉430030 [2]中南大学肾脏病研究所,湘雅二医院肾内科,长沙410011

出　　处：《中南大学学报（医学版）》2011年第10期1008-1011,共4页Journal of Central South University ：Medical Science

基　　金：湖南省自然科学基金(06JJ4020)~~

摘　　要：目的:揭示尿视黄醇结合蛋白(RBP)含量与肾小管间质受损的关系及其临床意义。方法:选择1 353例健康人群及186例经肾活检确诊的各种肾脏病患者为研究对象,均进行肌酐清除率(Ccr)、肌酐(Cr)、RBP、尿β2-微球蛋白(β2-MG)、尿N-乙酰-β-D-氨基葡萄糖苷酶(NAG)、尿比重(SG)、尿渗透压等项目的测定,并进行比较;同时将所有肾小管功能检测项目与肾小管间质受损评分进行Spearman等级相关分析,计算RBP含量与肾间质受损及受损程度的相关性和敏感性与特异性。结果:肾小管间质受损与尿RBP,β2-MG,NAG呈正相关(分别r=0.863,P<0.001;r=0.777,P<0.001;r=0.374,P=0.002);与渗透压,SG呈负相关(分别r=-0.519,P<0.001;r=-0.624,P<0.001);尿RBP含量对肾间质受损的特异性和敏感性为91.03%和72.06%。结论:尿RBP是反映近端肾小管功能的特异性标志物,可能对诊断、鉴别诊断各种肾脏疾病小管间质病理受损及受损程度具有重要临床意义。Objective To study correlation between urinary retinol binding protein（RBP） content and renal tubular damage.Methods A total of 1 353 healthy people and 186 patients with renal tubular damage diagnosed by renal biopsy were enrolled.The indicators such as endogenous creatinine clearance rate（Ccr）,creatinine（Cr）,urinary retinol binding protein（RBP）,urinary β2-microglobulin（β2-MG）,urinary N-acety1-beta-D-glucosaminidase（NAG）,urine specific gravity（SG）,urine osmolality of the 2 groups were examined and compared.Score of tubulointerstitial impairing and all indicators were analyzed by Spearman rank correlation analysis,and the sensitivity and specificity of indicators were calculated.Results Renal tubular damage was positively correlated with urinary RBP,β2-MG,NAG（r=0.863,P0.001;r=0.777,P0.001;r=0.374,P=0.002,respectively）,while negatively correlated with urine osmolaling,SG（r=-0.519,P0.001;r=-0.624,P0.001,respectively）.The specificity and sensitivity for renal tubular damage of RBP were 91.03% and 72.06%.Conclusion RBP is an idea marker for renal tubular damage,and is useful to diagnose renal tubular damage and assess the extent of the damage.

关 键 词：尿视黄醇结合蛋白 肾小管间质 受损 

分 类 号：R692.6[医药卫生—泌尿科学]