Identification of the Metabolite of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR  

作　　者：Feng, NP Zhang, ZX An, DK Huang, WL Wang, GJ Han, XW Bao, XH 

机构地区：[1]CHINA PHARMACEUT UNIV,NANJING 210009,PEOPLES R CHINA [2]CHINESE ACAD SCI,DALIAN INST CHEM PHYS,DALIAN 116023,PEOPLES R CHINA

出　　处：《Chinese Chemical Letters》1997年第6期515-518,共4页中国化学快报（英文版）

摘　　要：The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. Characterization and structural elucidation of the metabolite was achieved by LC/MS and LC/NMR.

分 类 号：O657.6[理学—分析化学]