抗生素对新生儿肠道菌群的影响  

EFFECTS OF ANTIBIOTIC ON NEONATAL INTESTINAL MICROFLORA

作　　者：秦雨春[1] 刘吉荣[1] 张玉[1] 徐放生[1] 吴婉芳[1] 

机构地区：[1]北京首都儿科研究所,100020

出　　处：《中国新生儿科杂志》1996年第5期197-198,223-238,共4页Chinese Journal of Neonatology

摘　　要：选择11例日龄7天以上新生儿肺炎住院病儿分别于没用头饱呋肟治疗前、治疗后1天、4天、7天做肠道菌群分析，同时检测10例持续应用抗生素3－8周病儿的肠道菌群。结果显示抗生素对肠道厌氧菌群的影响以治疗后1天最明显，对需氧菌的影响在第7天最明显，而对长期使用抗生素者表现在肠道菌群比例的严重失调及敏感菌量的再次增多，提示长期应用抗生素可能造成微生态平衡紊乱及耐药性的产生，为继发感染提供了条件。The intestinal microflora were analyzed in 11 neonatal pneumonia cases before and 1、4、7th day after treatment with Cefuroxime. The microflora were also examined in 10 cases after long -term antibiotic usage (3- 8 weeks). The results demonstrated that anaerobic microflora were significantly affected at 1th day, and aerobic microflora were significantly affected at 7th day after treatment. The balance of microflora were severely disturbed after long-term treatment, this perhaps will be a condition for subsequent infection.

关 键 词：抗生素 新生儿 肠道菌群 

分 类 号：R722.13[医药卫生—儿科]