Effect of Different Drugs on End-tidal Carbon Dioxide during Rodent CPR  

作　　者：潘铁成 周淑华 

出　　处：《Journal of Huazhong University of Science and Technology(Medical Sciences)》1997年第4期244-246,共3页华中科技大学学报（医学英德文版）

摘　　要：The purpose of this study was to investigate the effect of nonadrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2(ETCO2)during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension- Ⅱ(ANG- Ⅱ), but not by endothelin-1 (ET-1): 2) ETCO2 prior to defibrillation was decreased significantly by a pure a1 adrenergic agents,methoxamine and were increased significantly by non-adrenergic agents, ANG-Ⅱ and ET-1 during rodent CPR;3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-Ⅱ have similar effect on resuscitability during rodent CPR.The purpose of this study was to investigate the effect of nonadrenergic agents on cardiopulmonary resuscitation (CPR) and end-tidal CO2(ETCO2)during CPR in a rodent model. Our results suggested that: 1) coronary perfusion pressure (CPP) after drugs infusion was increased significantly by methoxamine, arginine vasopresin (AVP) and angiotension- Ⅱ(ANG- Ⅱ), but not by endothelin-1 (ET-1): 2) ETCO2 prior to defibrillation was decreased significantly by a pure a1 adrenergic agents,methoxamine and were increased significantly by non-adrenergic agents, ANG-Ⅱ and ET-1 during rodent CPR;3) a significant positive correlation between ETCO2 and CPP was observed in AVP group, suggesting that AVP have little effect on pulmonary circulation; and 4) methoxamine, AVP and ANG-Ⅱ have similar effect on resuscitability during rodent CPR.

关 键 词：cardiopulmonary resuscitation coronary perfusion pressure end-tidal carbon dioxide METHOXAMINE arginine vasopressin angiotensin-Ⅱ endothelin-1 

分 类 号：R965[医药卫生—药理学]