面部原发性皮肤隐球菌病1例  

A case of primary cutaneous cryptococcosis in the face

作　　者：葛红芬[1] 王桂芝[1] 臧运书[1] 汤占利[1] 韩莎莎[1] 王君[1] 

机构地区：[1]青岛大学医学院附属医院,青岛266003

出　　处：《中国真菌学杂志》2011年第5期298-300,共3页Chinese Journal of Mycology

摘　　要：报道1例自身免疫功能正常的原发性皮肤隐球菌病。患者因"面部红斑进行性加重半年,破溃伴结痂2个月余"来我科就诊,皮肤科检查可见左侧面颊部3 cm×5 cm大小红斑,边界清楚,中央可见数片浅溃疡,覆盖灰褐色痂皮。病理检查示真皮浅层及深层可见大量炎性细胞浸润,PAS染色见大量紫红色孢子聚集在多核巨细胞内外;阿申蓝染色阳性;粘蛋白卡红染色阳性;免疫组化染色(抗体为兔抗隐球菌抗体)可见棕色圆形孢子。根据其临床症状、病理检查、特殊染色及免疫组化染色,确诊为原发性皮肤隐球菌病。经伊曲康唑治疗痊愈。A case of primary cutaneous cryptococcosis in an immunocompetent-woman was reported.Erythema（3 cm×5 cm）with clear border and ulcers in the middle has been existed in the left face for about half a year.Granulomatous infiltration with mauve bodies were found by PAS staining.Cryptococcus spores were identified by alcian staining,mucicarmine staining and immunohistochemistry staining.The patient was diagnosed as primary cutaneous cryptococcosis and was cured with itraconazole（400 mg/d daily）.

关 键 词：隐球菌病 皮肤 原发性 

分 类 号：R519.4[医药卫生—内科学]