肝细胞生长因子和丹参对大鼠急性肝损伤保护作用的实验研究  

PROTECTIVE EFFECTS OF HGF AND SALVIA MILTIORRHIZA ON ACUTE LIVER INJURY INDUCED BY CCI_4 IN RATS

作　　者：潘其声[1] 刘怡晟[1] 

机构地区：[1]南京铁道医学院附属医院,南京210009

出　　处：《实用临床医药杂志》1997年第3期173-176,共4页Journal of Clinical Medicine in Practice

摘　　要：作者观察了肝细胞生长因子（HGF）、丹参对DDl4所致大鼠急性肝损伤的影响，结果发现，HGF组、丹参组以及西药联用组对急性肝损伤大鼠的血清ALT、α-肿瘤坏死因子（TNF-α）、丙二醛（MDA）以及肝组织匀浆MDA、肝组织钙含量的升高等均有不同程度的降低作用，且能使CCl4所致降低的血清及肝组织匀浆SOD活力明显升高。光镜及电镜下观察，用药组肝细胞病变软CCl4组有明显改善。本文结果表明，HGF、丹参对CCl4所致大鼠急性肝损伤有良好的保护作用，且HGF、丹参联用效果优于单用．We observed protective effects of hepatic growth factor (HGF) and salvia miltiorrhiza (SM) on acute liver injury induced by CCl4 in rats. Acute liver injury of rats was induced by CCl4 administered introperitoneally. Animals were divided into 5 groups: CCl4, HGF, SM, HGF+SM and normal groups. After given above drugs at different time, serum A and TNF-α were measured, the liver specimen was observed histological1y and the levels of MDA, SOD, Ca2+in liver tissue were compared among different groups. The results show that the levels of ALT, TNF-α, MDA, calcium, SOD and pathological changes of the liver were improved obviously in HGF or SM and HGF+SM groups. The protective effects in group HGF+SM were better than that in HGF or MS groups. HGF and SM have a good results in protectings hepatocyte degeneration and necrosis induced by CCl4 in rats,

关 键 词：肝细胞生长因子 丹参 超氧化物歧化酶 肿瘤坏死因子 急性肝损伤 

分 类 号：R965[医药卫生—药理学]