丹参提取物对大鼠纤维肝肝细胞摄入脯氨酸的影  

INFLUENCE OF THE EXTRACT OF RADIX SALVIAE MILTIORRHIZAE ON THE HEPATIC CELLS OF RATS OF.HEPATO FIBROSIS TAKEN IN PROLINE

作　　者：李旭东[1] 王树槐[1] 李登銮[2] 朱新华 陆伦根[1] 朱海杭[2] 朱瑞锦 王逢民[3] 

机构地区：[1]扬州大学医学院 [2]扬州大学医学院附属医院,扬州225001 [3]泰兴市人民医院,泰兴225400

出　　处：《实用临床医药杂志》1997年第5期324-326,共3页Journal of Clinical Medicine in Practice

摘　　要：用CCl4等攻击Wistar大鼠，致其肝纤维化。后将其随机分为苦杏仁甙（D）、丹参水溶性提取物（F）、冬虫夏草（E）、D加E（G）、秋水仙碱（C）及空白对照（B）组。均持续病因刺激。另设正常对照（A）组。在体预处理60d后，各实验药物组又随机区分为向和未向培养皿中添加药物，继续培养24h后，检测指标变化。结果表明：阳性药秋水仙碱抑制肝细胞摄入[3H]脯氨酸的作用最强；丹参水溶性提取物在病因持续存在条件下，仍能较强地阻抑肝细胞对[3H]脯氨酸的摄入，提示：①该药作用途径可能为多途径的；②可能有直接对抗病因的作用。苦杏仁甙、冬虫夏草的同一药理作用不及上述二药，但二药联用限定某一条件时，其作用可与秋水仙碱相当。Using CCl4 to attack the rats and to make them hepato fibrosis, we randomly divided them into several groups, apart form the normal control group, namthy Amygdalin (D), water soluble ex tractive of Radix Salviae Miltiorrhizae (F), Cordyceps (E), (D) plus (E) (G), Colchicum (C) and blank control (B). After 60 days of pretreatment, some of the culture plates were added medicine while others were not. After 24 hours of culture, the detection result changed, which showed that the inhibition of proline'intaking of posive Colchium was most effective. The water soluble extractive of Radix salviae Miltior rhizae could also cause the inhibition of, proline intaking.

关 键 词：丹参水溶性提取物 苦杏仁甙 冬虫夏草 秋水仙碱 肝纤维化 肝细胞 

分 类 号：R282[医药卫生—中药学]