Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) Contrast Agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups  

作　　者：Zhuo, RX Fu, YJ Liao, J 

机构地区：[1]WUHAN UNIV,DEPT CHEM,WUHAN 430072,PEOPLES R CHINA

出　　处：《Chinese Chemical Letters》1997年第2期157-160,共4页中国化学快报（英文版）

摘　　要：DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine (<(DP)over bar> 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.

分 类 号：O631[理学—高分子化学]