应用荧光偏振免疫法监测肾移植患者全血环孢素A浓度的临床评价  

The Clinical Significance of Monotoring Whole Blood Concentration of CsA in Renal Transplant Recipients

作　　者：田普训[1] 陈勇 薛武军[1] 邢俊平[1] 燕航[1] 丁小明[1] 王茂义[2] 闫正华[2] 马瑛[2] 张华安[2] 

机构地区：[1]西安医科大学第一附属医院肾移植科,西安710061 [2]西安医科大学第一附属医院药剂科,西安710061

出　　处：《现代泌尿外科杂志》1997年第4期217-220,共4页Journal of Modern Urology

摘　　要：应用荧光偏振免疫法(FPIA)对274例肾移植术后患者行2312人次全血环孢素A(CsA)浓度测定。结果分析表明:(1)CsA在三联免疫抑制疗法中的理想治疗窗浓度范围是:术后第1、2、3和4～12个月全血CsA浓度分别为300～430、280～350、180～280和110～250ng/ml;(2)FPIA法具有快速、准确、操作简便,适于批量测定等优点。讨论了肝肾中毒、排斥反应、高危人群及合并用药与全血CsA浓度的关系。Whole blood concentration of CsA was assayed 2312 times in 274 renal transplant recipientsby the fluorescence polarization immunoassay (FPIA, abbott TDx). In the 1st, 2nd, 3rd and 4~12 th month post kidney transplantation) the ideal therapeutic window range of whole blood CsA level was 300~430,280 ~350,180~280 and 110-250 ng/ml respectively for patients on triple immuno-suppressive therapy. FPIA is precise, Sensitive, rapid and easy to carry out. The correlation between hepatotoxcity. nephrotoxcity of CsA, rejection, old and risk recipients and whole blood CsA level was discussed.

关 键 词：移植 肾 环孢霉素A 

分 类 号：R699[医药卫生—泌尿科学]