益气活血中药对犬心肌缺血模型保护作用的实验研究  

Experimental Study on Protecting Effects of Yiqi Huoxue(益气活血)Recipe in Myocardial lschemic Models in Dogs

作　　者：黄惠生[1] 谭毓治[1] 汤益明[1] 张庭玉[1] 蔡美华 

机构地区：[1]江西省中医药研究所,南昌330006

出　　处：《中国中西医结合杂志》1996年第S1期6-8,273-274,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：健康成年杂种犬10只,分为补气强心汤组(中药组)5只及生理盐水组(对照组)5只。心肌缺血模型由结扎左冠状动脉前降支(1和2分支间)而建立。用多导生理记录仪经左心导管分别测定左室内压峰值(LVSP)、左室舒张末压(LVEDP)、左室压力上升或下降最大速率(±dp/dtmax)及左室舒缓时间常数(T-C)、心率(HR)。冠脉结扎后,实验犬均示LVSP、±dp/dtmax 下降、LVEDP 增加、HR 减慢、T-C 延长等效应,但除 HR 外其他心功率参数在中药组其变化均明显小于对照组(P<0.05～0.01)。解除结扎心肌复灌后,上述参数均进一步恶化,但其程度同样中药组明显小于对照组(P<0.05～0.01)。采用四氮唑蓝心肌活体染色法计算坏死心肌重量与心脏总重量的百分率,中药组为7.40±0.60%,对照组为9.75±0.97%,两组比较有显著差异(P<0.005)。因而本研究证明益气活血中药对实验犬冠脉阻断造成的急性心肌缺血模型的心功能及心肌损伤具有保护效应。Ten healthy and hybrid dogs were divided into Buqi Qiangxin decoction(补气强心汤) medicated group(5 dogs) and control group (5 dogs).The myocardial ischemia models were produced by ligating the left coronary artery between the branches 1 and 2 among the anterior descending branches.Peak left ventricular systolic pressure(LVSP),left ventricular end-diastolic pressure(LVEDP),±dp/dtmax,constant of isovolumie relaxation(T-C) and heart rates(HR) were record- ed.After ligation,LVSP and±dp/dtmax and HR were decreased,LVEDP increased,T-C were prolonged,but the changes of all indices except HR in medicated group were significantly smaller than that of control group(P<0.05～0. 01).After reperfusion,the left ventricular function were deteriorated progressively,but the effects were also significantly smaller in medicated group(P<0.05～0.01).Using nitroblue tetrazolium staining method to calculate the area of necrot ie myocardium,the results were as follows:weight of necrotic myocardium/weight of total heart were 7.4±0.6% in medicated group and 9.75±0.97% in control group(P<0.05).these results showed that Yiqi Huoxue Decoction ex- erts obvious protective effects against myocardial injury induced by ischemia/reperfusion.

关 键 词：益气活血药 心导管检查 急性心肌缺血 左室功能 

分 类 号：R285.5[医药卫生—中药学]