参附注射液对内毒素休克大鼠保护作用的实验研究  

The Experimental Research on the Protective Effect of Shengfu Injection(参附注射液)on Endotoxic Shock in Rats

作　　者：陈广文[1] 皮业庆[1] 尢家騄[1] 罗正曜[1] 万兰清[2] 马超英[2] 

机构地区：[1]湖南医科大学病理生理教研室,长沙410078 [2]江西中医学院热病研究室

出　　处：《中国中西医结合杂志》1996年第S1期72-74,281-282,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金课题

摘　　要：感染性休克中医辨证为闭证、脱证或内闭外脱证。本实验用大鼠内毒素休克动物模型和中医固脱法,从微循环角度观察了中药制剂参附注射液对内毒素休克大鼠的保护作用。结果显示:参附注射液能提高内毒素休克大鼠存活率,延长存活时间,明显改善微循环,促进血压恢复。为临床应用固脱中药参附注射液抢救感染性休克提供了实验依据。The protective effect and mechanism of Shengfu injection on endotoxic shock in rats were investigated by observing the changes of blood pressure,survival rate,survival time and microcirculation of musculus cremaster.Sixteen male Wis- tar rats were divided into two groups(8 in each)randomly.(1)Shengfu group:Shengfu injection was given intravenously (0.5ml/100g iv)30 rain before the E.Colt endotoxin was given(ET,2×10^(11)died bacteria/kg,iv).(2)normal saline (NS)group:NS iv 30 min before the ET iv.The results revealed:Blood pressure of Shengfu group after injection of ET decreased less and recovered faster than their of NS group,Blood flow of microcirculation in the group of Shengfu was faster than that of NS group.Survival rate of Shengfu group was obviously higher,average survival time of Shengfu group was obviously longer than those of NS group.It suggested that:Shengfu injection dies have protective effect on endotoxic shock.Its mechanism is related to the improvement of microcircutation.

关 键 词：感染性休克 大鼠 血压 存活率 微循环 参附注射液 

分 类 号：R285.5[医药卫生—中药学]