青心酮对晚孕家兔子宫动脉血流量的影响  

Effect of Dihydroxyacetophyenone on Uterine Artery Blood Flow of Rabbits in Late Pregnancy

作　　者：闪珍珍[1] 司远征[1] 熊忠明[1] 吴熙瑞[1] 

机构地区：[1]同济医科大学生殖医学中心,武汉430030

出　　处：《中国中西医结合杂志》1996年第S1期204-206,300,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：通过青心酮对晚孕家兔子宫动脉血流量等影响的直接动态观测,探讨青心酮用于改善子宫胎盘血循可能的作用机制及剂量——反应关系。结果表明,青心酮具有降低母体动脉血压及增加子宫动脉血流量的作用,并呈现明显剂量依赖关系,以10mg/kg 时作用最明显。青心酮明显改善子宫胎盘血液循环,因此有可能发展成为防治妊娠高血压综合征和胎儿宫内生长迟缓等子宫胎盘血循不良疾病的有效药物。The effect of dihydroxyacetophenone(DHAP) on uterine artery blood flow of rabbits in late pregnancy was investigat- ed quantitatively by means of the electromagnetic flowmeter.The results demonstrated that uterine artery blood flow in- creased significantly and at the same time the maternal arterial blood pressure lowered after DHAP was given.Further- more there was a dose-response dependent relationship between the doses of the DHAP and effects.The increase of uterine artery blood flow was most significant when the drug was given in the dosage of 10 mg/Kg.Therefore it is supposed that DHAP might be an effective agent for treating pregnancy induced hypertension and intrauterine growth retartation,both accompanied by disturbance of uteroplacental circulation.

关 键 词：青心酮 子宫动脉 血流量 妊娠家兔 

分 类 号：R285.5[医药卫生—中药学]