四种阳虚动物模型细胞免疫变化比较  

The Comparison of Immunological Function Changes Between Four Yang Deficiency Animal Models

作　　者：何玲[1] 董庆滨[1] 那爱华[1] 王典瑞[1] 梁兆祥[1] 马爱新[1] 南景一[1] 

机构地区：[1]空军医学高等专科学校,吉林132011

出　　处：《中国中西医结合杂志》1996年第S1期255-256,308-309,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本研究用腹腔注射醋酸氢化泼尼松、喂饲甲基硫氧嘧啶、喂饲羟基脲和腹腔注射利血平等方法复制了4种小鼠阳虚模型,然后观察其部分细胞免疫功能变化。结果表明:4种模型小鼠的各项免疫指标均明显低于对照组,各模型之间免疫指标的改变也存在显著差异。本实验结果进一步证明了免疫功能降低是阳虚证的机制之一,并初步认为醋酸氢化泼尼松和羟基脲是制作阳虚模型更理想的药物。Four Yang Deficiency mice models were made in this experiment with intraperitoneal prednisolone acetate and Reser- pin injection,methylthiouracil and hydroxyurea feeding.Then the cell immunity changes in each animal group were ob- served.The results showed that every item of immunological indices in all animal models was markedly lower than that in normal control group.Also,significant difference could he found between the four mice models.These findings further demonstrate that immunological functional insufficiency is one of the Yang Deficiency mechanisms.It suggested that pred- nisolone acetate and hydroxyurea are more ideal drugs for Yang Deficiency animal model making.

关 键 词：甲基硫氧嘧啶 利血平 免疫功能 羟基脲 阳虚模型 

分 类 号：R255[医药卫生—中医内科学]