STUDIES OF QINGYANGSHEN (Ⅱ): MODULATORY EFFECT OF CO-TREATMENT WITH QINGYANGSHEN AND DIPHENYLHYDANTOIN SODIUM ON RAT HIPPOCAMPAL c-fos EXPRESSION DURING SEIZURES  

作　　者：郭庆 匡培根 

机构地区：[1]Neurotransmitter Laboratory, Department of Neurology, Chinese PLA General Hospital, PLA Postgraduate Medical School, Beijing 100853, P.R.China * Present address: Department of Neurobiology, Institute of Basic Medical Sciences, Academy of Military Medical Sciences, No. 27 Taiping Road, Beijing 100850, China

出　　处：《Journal of Traditional Chinese Medicine》1996年第1期48-50,共3页中医杂志（英文版）

摘　　要：We have reported that, after KA treatment in rats, there was first a significant increase hi hippocampal c-fos expression daring acute seizures and then a long-term inhibition in hippocampal c-fos expression duing chronic seizures. In this experiment, we examined the modulatory effect of Qingyangshen (QYS), a traditional Chinese medicine with antiepileptic property, and diphenylhydantoin sodium (DPH) on hippocampal c-fos expression during seizures. We found that after intra peritonea I injection of QYS+DPH (15 mg/ kg and 50 mg/ kg respectively, q.o.d. x 6), the peak level of hippocampal c-fos mRNA induction during KA-in-duced acute seizures was reduced by 56.27%; while the inhibition of hippocampal c-fos expression during KA-induced chronic seizures was disinhibited to control level. It is suggested that the inhibitory effect of QYS+DPH on KA-induced seizures, chronic seizures in particular, may have much to do with its modulatory effect on hippocampal c-fos expression.We have reported that, after KA treatment in rats, there was first a significant increase hi hippocampal c-fos expression daring acute seizures and then a long-term inhibition in hippocampal c-fos expression duing chronic seizures. In this experiment, we examined the modulatory effect of Qingyangshen (QYS), a traditional Chinese medicine with antiepileptic property, and diphenylhydantoin sodium (DPH) on hippocampal c-fos expression during seizures. We found that after intra peritonea I injection of QYS+DPH (15 mg/ kg and 50 mg/ kg respectively, q.o.d. x 6), the peak level of hippocampal c-fos mRNA induction during KA-in-duced acute seizures was reduced by 56.27%; while the inhibition of hippocampal c-fos expression during KA-induced chronic seizures was disinhibited to control level. It is suggested that the inhibitory effect of QYS+DPH on KA-induced seizures, chronic seizures in particular, may have much to do with its modulatory effect on hippocampal c-fos expression.

关 键 词：青阳参 实验观察 培根 形成过程 基因表达变化 海马结构 医药信息 癫痫大发作 抗惊厥药 神经系统疾病 

分 类 号：R285[医药卫生—中药学]