T　LYMPHOCYTE　SUBSETS　OF　PERIPHERAL　BLOOD　AND　THEIR　RELATIONSHIP　WITH　BETA－2－MICROGLOBULIN　IN　MULTIPLE　MYELOMA  

作　　者：郑成云 陈学民 王宝燕 陈开浚 

出　　处：《Journal of Pharmaceutical Analysis》1996年第1期77-79,共3页药物分析学报（英文版）

摘　　要：patients with multiple myeloma (MM) were investigated for lymphocyte subsets using APAAP (Alkaline Phosphastase Anti-Alkaline Phosphatase) technique and a panel of monoclonal antibodies.Radioimmunoassay was used to examine serum beta-2-microglobulin (Sβ2-MG).The results showed that OKT3, OKT4 positive cells and OKT4/OKT8 ratio reduced significantly. OKT8 positive cells increased sharply in MM. We conclude that,in MM,all patients have severe abnormalities in the number and proportion of T cells.The level of S β2-MG increased significantly, especially in the initial and relapsing patients.But,we did not find the relationship between Sβ2-MG and T subsets.patients with multiple myeloma (MM) were investigated for lymphocyte subsets using APAAP (Alkaline Phosphastase Anti-Alkaline Phosphatase) technique and a panel of monoclonal antibodies.Radioimmunoassay was used to examine serum beta-2-microglobulin (Sβ2-MG).The results showed that OKT3, OKT4 positive cells and OKT4/OKT8 ratio reduced significantly. OKT8 positive cells increased sharply in MM. We conclude that,in MM,all patients have severe abnormalities in the number and proportion of T cells.The level of S β2-MG increased significantly, especially in the initial and relapsing patients.But,we did not find the relationship between Sβ2-MG and T subsets.

关 键 词：T lymphocyte subsets beta-2-microgiohulin multiple myeioma 

分 类 号：R331.5[医药卫生—人体生理学]