左旋氧氟沙星对氨茶碱药物动力学的影响  

THE EFFECT OF LEVOFLOXACIN ON PHARMACOKINETICS OF AMINOPHYLLINE IN HEALTHY VOLUNTEERS

作　　者：朱永泉[1] 谢守霞[1] 宁德俄[1] 董淳[1] 

机构地区：[1]深圳市人民医院药剂科临床药学室,深圳518020

出　　处：《中国临床药学杂志》1996年第4期141-143,共3页Chinese Journal of Clinical Pharmacy

摘　　要：采用荧光偏振免疫分析法(FPIA),在7名志愿者身上,对氨茶碱单用及与左旋氧氟沙星合用后,血中氨茶碱浓度的变化进行观测.结果表明,合用左旋氯氟沙星后氨茶碱消除速率常数k降低13.6%,清除率CL下降15.6%,半衰期T_1/2延长16.5%(P<0.05),但对峰浓度C_(max)、曲线线下面积AUC,表观分布容积V_d无显著影响(P<O.05).Aminophylline in blood was determined by FPIA for 7 healthy volunteers having taken aminophylline or aminophylline combined with levofloxacin. The results indicated that levofloxacin made the elimination half life of aminophylline prolong,clearance and elimination rate constant reduced (P<0. 05). There was no significant statistical differences in the apparent distribution volume, the area under the curve and the peak concentration of aminophylline.

关 键 词：左旋氧氟沙星 氨茶碱 药物动力学 

分 类 号：R96[医药卫生—药理学]