氯唑沙宗片的药动学及相对生物利用度  

PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF CHLORZOXAZONE TABLET IN 10 HEALTHY VOLUNTEERS

作　　者：张宏伟[1] 李巧云[1] 杨香媛[1] 李端[1] 郁韵秋[2] 

机构地区：[1]上海医科大学药学院药理教研室,200032 [2]上海医科大学药学院药物分析教研室,200032

出　　处：《中国临床药学杂志》1996年第2期54-57,共4页Chinese Journal of Clinical Pharmacy

摘　　要：在10名健康志愿者进行了两种氯唑沙宗片的药动学比较.按交叉试验设计,Po给药,用高效液相色谱法测定氯唑沙宗的血药浓度,其药时曲线符合一室模型.待测片的药动学参数:C_(?)=12.30±3.74μg/ml,Td_(?)=1.13±0.23h,K=0.88±0.15h,T_(1/2)=0.81±0.14h,AUC_(0～(?)h)=31.49±10.60μg·h/ml.待测片的相对生物利用度为107.21%,与标准片具有生物等效性.A pharmacokinetics and relative bioavailability study of randomized cross-over design was carried out in ten healthy men who were given a single oral dose of chlorzoxazone in either of the two tablet formulations. Serum levels were determined by HPLC method. The concentration-time curve was fitted with a one compartment model. The pharma-cokinetic parameters of the detected tablet were as follows Cmax=12.30±3.74μg/ml, Tmax=1.13±0.23h, K=0.88±0.15h-1, T=0.81±0.14h, AUC0-8h=31.49±10.60μg·h/ml,In comparison with the standard tablet, the detected tablet is bioequivalent.

关 键 词：氯唑沙宗 药代动力学 生物利用度 高效液相色谱法 

分 类 号：R969.1[医药卫生—药理学]