血流动力学在动脉粥样硬化形成中作用的实验研究  

A Study on the Role of Hemodyuamics in Atherosclerosis

作　　者：周传恩 王瑞英[2] 

机构地区：[1]恩施医专附属医院 [2]湖北医科大学附属二医院

出　　处：《湖北民族学院学报（医学版）》1995年第1期5-9,共5页Journal of Hubei Minzu University(Medical Edition)

摘　　要：为探讨血流动力学在动脉粥样硬化形成中的作用,将28只雄性大耳白兔随机分为四组,于模型组,模型十胆固醇组行动静脉造瘘吻合,实验中测定脂类代谢指标总胆固醇（Tch）、甘油三酯（TG）、高密度酯蛋白（HDL—C）、血钙、羟脯氨酸（HY）浓度及组织生化（Ich、Ca、Hy）,结果显示:1、血流动力学干扰可致Ch、Ca沉积于管壁并致管壁脯氨酸升高（模型组,模型十胆固醇组与正常组,胆固醇组比较P<0.05或<0.01）。2、血流动力学调控着血管壁的饮食诱导性脂质沉积（模型十胆固醇组与胆固醇组组织Ch比较P<0.01）。3、血流动力学干扰可不依赖于血浆脂质水平（模型组与正常组及实验前比无差异P>0.05）而致AS改变（光镜及电镜结果产生AS改变）。To go further into the role of hemodynamics in atherosclerosis 28 male rabbits were divided into 4 groups at random.Arteriovenots fistulae were fashioend in model group and model+cholesterol group before experiment. Blood indices concerning lip id metabolism (Tch, TG, HDL-C), serum calcium levels hydroxyproline concentration and histochemical ( Teh, Ca, Hy ) were observed at experiment. Results of this study showed ( 1 ) Disturbance of hemodynamics produced deposition of cholesterol and calcium and led to elevated Hydroxyproline in the blood vessel wall.( 2 ) Hemodynamics governed dietazy induced lipid deposition. ( 3 ) Disturbance of hemodynamics can induce the change of atheros-clrosises inaependendenlyof serum cholesterole lvels

关 键 词：血流动力学 动脉粥样硬化 胆固醇 

分 类 号：R543.5[医药卫生—心血管疾病]