国产格列齐特治疗非胰岛素依赖型糖尿病112例近期疗效观察  

Observed of short-term efficacy of domestic gliclazide in the treatment of noninsulin-dependent diabetes mellitus in 112 patients

作　　者：王竹兰[1] 冯根宝[1] 田成功[2] 朱大龙[2] 唐尧[3] 葛祖恺[3] 何戎华[4] 陈家伟[4] 

机构地区：[1]南京军区南京总医院内分泌科,南京210002 [2]南大医学院附属鼓楼医院内分泌科 [3]南京铁道医学院附属第一医院内分泌科 [4]南京医科大学附属第一医院内分泌料

出　　处：《医学研究生学报》1995年第2期122-126,共5页Journal of Medical Postgraduates

摘　　要：应用国产格列齐特治疗112例NIDDM患者，其有效剂量为111．1±64．8mg／d（20～240mg／d），显著低于进口达美康；有效率为99．11％，显著高于进口达美康；国产格列齐特除具有降糖、降糖化血红蛋白、促进胰岛素分泌、提高血清基础胰岛素水平、降低血浆纤维蛋白原作用外，还具有调整脂类代谢紊乱的作用，其效果亦优于进口达美康。国产格列齐特生物利用度高，安全有效，是NIDDM患者的一种理想口服降糖药。Domestic gliclazide was used to treat 112 Patients with noninsulin-dependent diabetes rnellitus (NIDDM ). The other 93 were medicated with imported diamicron as controls. The daily oral dose of domestic glicazide ranged from 20~240 (111. 1± 64. 8) mg. After a 2~3 month course of treatment, mean fasting and 2-hour postprandial blood glucose, plasma fibrlnogen, urine glucose excretion and glucohemoglobin levels were reduced significantly (P<0. 01 ), glucose tolerance was elevated,serum insulin levels in fasting and each phase after glucose loading were increased appreciably (P<0. 01 ),disorder of lipin metabolism was improved in domestic gliclazide group. The efficacy dose of domestic gliclazide was more lower than that of imported diamicron. Therapeutic efficacy and bioavailabiliaty were more higher than that of irnported diamicron. Side effect of domestic gliclazide was minimal, similar to that of imported diamicron. The result of Survey indicated domestic gliclazide was a effictive,safe oral hypoglucemic agent in NIDDM.

关 键 词：格列齐特 非胰岛素依赖型糖尿病 达美康 

分 类 号：R587.1[医药卫生—内分泌]