抗CCP抗体与类风湿关节炎临床表现的相关性  

Correlation of anti-CCP antibody and the clinical manifestations of rheumatoid arthritis

作　　者：沈桂英[1] 崔刘福[2] 杨文浩[2] 舒荣[2] 宋海澄[2] 韩依轩[2] 陆艳萍[2] 于萍[2] 王建[2] 王洁蕊[2] 袁伟[2] 

机构地区：[1]河北省唐山市协和医院消化内科,河北唐山063000 [2]华北煤炭医学院附属开滦医院风湿免疫科,河北唐山063000

出　　处：《中国医药导报》2011年第33期59-61,共3页China Medical Herald

基　　金：河北省科技厅科技攻关计划(编号:10276105D-7)

摘　　要：目的:探讨抗环瓜氨酸肽抗体(抗CCP抗体)与类风湿关节炎(RA)的临床表现的相关性。方法:收录139例RA患者的临床表现及X线分期。以酶联免疫吸附(ELISA)法测定其抗CCP抗体水平,抗类风湿因子(RF)采用乳胶凝集法测定,魏氏法测定血沉(ESR)。结果:抗CCP抗体阳性患者在血沉的分布(阴性vs阳性)、X线分期的分布(Ⅰ+Ⅱ期vsⅢ+Ⅳ期)、关节外表现的分布(<3个vs≥3个)、DAS 28评分的分布(>5.1分vs≤5.1分)方面与抗CCP抗体阴性患者比较,差异均有高度统计学意义(χ2=14.89、6.87、14.63、7.27,均P<0.01)。结论:抗CCP抗体与病情活动的指标(血沉、DAS 28评分)有关,与RA患者关节破坏程度(X线分期)和关节外表现有关。Objective： To explore the correlation between anti-cyclic citrullinated peptide（CCP） antibody and the clinical manifestations of rheumatoid arthritis（RA）.Methods： 139 patients with RA were evaluated（functional class,joint count,hands X-ray）.Anti-CCP antibody serum titres were measured by the anti-CCP enzyme linked immunosorbent assay（ELISA）.Rheumatoid factor（RF） was detected by latex agglutination.Erythrocyte sedimentation rate was detected by Wen＇s method.Results： There were statistical differences of the ESR positive and negative,Ⅰ＋Ⅱ stage of X ray group and Ⅲ＋Ⅳ,different extra articular manifestations,DAS 285.1 scores and DAS 28≤5.1 scores between the positive anti-CCP antibody group and the negative anti-CCP antibody group（χ2=14.89,6.87,14.63,7.27,all P0.01）.Conclusion： Anti-CCP antibody is correlated with ESR,the disease activity score 28（DAS 28）,stage of X ray and extra articular manifestations in RA patients.

关 键 词：抗环瓜氨酸肽抗体 类风湿关节炎 DAS28评分 关节外表现 X线分期 

分 类 号：R593.22[医药卫生—内科学]