疗癣卡西甫散的药效学研究  

Study on the effect of Liao Xuan Kaxipu San

作　　者：彭晓明 霍仕霞 吴培培[3] 闫明 高莉 

机构地区：[1]新疆维吾尔医药研究所,新疆乌鲁木齐830049 [2]新疆维吾尔医方剂学实验室,新疆乌鲁木齐830049 [3]新疆维吾尔自治区石河子大学药学院,新疆石河子832003

出　　处：《中国医药导报》2011年第33期64-66,共3页China Medical Herald

基　　金：新疆维吾尔自治区自然科学基金项目(项目编号:2009211B38)

摘　　要：目的:探讨疗癣卡西甫散的药效作用,并比较传统粉末制备与现代工艺制备间药效的差异。方法:根据药物对小鼠阴道上皮细胞有丝分裂变化的作用以及药物含药血清对角质形成细胞增殖作用的影响,评价药效作用,并对比分析传统粉末制备组(粉末组)与现代工艺制备组(浸膏组)之间的药效。结果:疗癣卡西甫散各制备组均能够显著抑制小鼠阴道上皮细胞的有丝分裂,对角质形成细胞的增殖具有抑制作用,且现代工艺制备组对小鼠阴道上皮细胞的有丝分裂和角质形成细胞的增殖抑制作用较之传统粉末组有所增强。结论:疗癣卡西甫散对银屑病具有治疗作用,且现代工艺制备组的药效作用明显优于传统粉末制备组。Objective： To investigate the medicine effect of Liao Xuan Kaxipu San and compare the effect differences between traditional powder and modern technics.Methods： The medicine effect differences were evaluated by observing the mitosis changes in mice vaginal epithelial cell and the influence of the proliferation effect to keratinocytes in medicated serum,then the medicine effects between traditional powder group（powder group） and modern technics group（extracts group） were compared and analysed.Results： All groups of the Liao Xuan Kaxipu San could restrain the mitosis in mice vaginal epithelial cell and the proliferation effect to keratinocytes,and the inhibition effect in the modern technics group was stronger than that in the traditional powder group.Conclusion： The Liao Xuan Kaxipu San has treatmental effect on psoriasis and the effect of the modern technics is better than that of the traditional powder group.

关 键 词：疗癣卡西甫 银屑病 药效 评价 

分 类 号：R285.5[医药卫生—中药学]