甲状腺CT值替代甲状腺摄^(131)Ⅰ率在^(131)Ⅰ治疗Graves病中的剂量计算  

Dosimeter of CT value of thyroid substitute for thyroid ^(131)Ⅰ intake rate in the treatment of Graves disease

作　　者：单东风[1] 宋玲[1] 张新弟[1] 李卫娟[1] 刘志明[2] 张宝雷[3] 

机构地区：[1]河北省廊坊市人民医院核医学科,河北廊坊065000 [2]河北省廊坊市人民医院放射科,河北廊坊065000 [3]廊坊师范学院数学与信息科学学院,河北廊坊065000

出　　处：《中国医药导报》2011年第33期100-102,共3页China Medical Herald

摘　　要：目的:通过对Graves病(GD)患者甲状腺CT值与甲状腺摄131Ⅰ率间关系研究,进一步探讨二者能否在131Ⅰ治疗剂量计算公式中互换。方法:对105例GD患者甲状腺CT值和甲状腺摄131Ⅰ率等相关资料进行分组,计算平均值,行多元方差分析,通过Logit变换、双变量相关分析,推导甲状腺CT值与甲状腺摄131Ⅰ率间关系式,再将此关系式带入GD患者131Ⅰ治疗用药剂量计算公式进行实际应用检验,将计算结果与实际用药量做对照。结果:①甲状腺CT值与甲状腺摄131Ⅰ率和甲状腺重量呈负相关。②多元方差分析甲状腺CT值与摄131Ⅰ率间具有相关性,K-S检验服从正态分布。并经推导获二者关系式:X=exp(a+b×CT值)/[1+exp(a+b×CT值)],a=4.331 8,b=-0.033 6,差异有高度统计学意义(F=51.071,P=0<0.01)。应用检验,其计算结果与实际用药量对比,相对误差绝对值及绝对误差绝对值均<5%,其误差在允许范围内。结论:二者间存在很好相关性,并在一定范围内可相互替换。Objective： To research the relationship between CT value of thyroid and thyroid 131Ⅰ intake rate in the treatment of patients with Graves disease（GD）,and then discuss whether they can be interchanged between the thyroid 131Ⅰ uptake rate and CT value in dose calculation formula of 131Ⅰ of Graves disease.Methods： The clinical data of thyroid CT value and thyroid 131Ⅰ intake rate of 105 patients with Graves disease were divided into groups,the average value was calculated,multivariate analysis of variance was used,the related analysis of the formula of thyroid CT value and thyroid 131Ⅰ intake rate were derived by Logit transformation and bivariate,then formula was put in drug dosage of 131Ⅰ calculation formula of patients with Graves disease in order to compare the calculation results and practical dosage.Results： ①There was a negative correlation among CT value,131Ⅰ uptake rate and thyroid weight.②The results of multivariate analysis showed that there was a correlation between CT value and 131Ⅰ uptake rate.The results of K-S test showed that CT value and 131Ⅰ uptake rate obeyed the normal distribution.Derived formula of them： X=exp（a＋b×ValueCT）/[1＋exp（a＋b×ValueCT）],a=4.331 8,b=-0.033 6,there was a significant difference（F=51.071,P=00.01）.The test was applicated to compared calculation results and practical dosage,absolute value and absolute error absolute value were all 5%,error was allowable.Conclusion： The relation between the CT value of thyroid and thyroid 131Ⅰ intake rate has nice relativity,and they can be used interchangeably within limits.

关 键 词：GRAVES病 甲状腺CT值 甲状腺摄131Ⅰ率 相关性 

分 类 号：R581[医药卫生—内分泌]