绞股蓝总皂甙对大鼠心室纤颤阈值和血浆TBA反应值的影响  

Effects of Gypenosides on Ventricular Fibrillation Threshold and Plasma Thiobarbituric Acid Value in Rats

作　　者：余涓[1] 汪雄[2] 陈刚[2] 

机构地区：[1]福建医学院病理生理教研室,福州350004 [2]湖北郧阳医学院病理生理教研室

出　　处：《中国中西医结合杂志》1995年第S1期30-32,366,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：利用电致颤动物模型,发现50mg/kg 绞股蓝总皂甙(GP)静脉注射可明显提高大鼠心室纤颤阈值(VFT)。用药后15、30、45、60、75min,VFT 从2.75±0.21mA 升高到6.40±1.49mA、6.95±1.21mA、5.70±0.90mA、4.95±0.86mA、4.50±0.70mA,分别与基础值和生理盐水(NS)组比有明显差异(P<0.05,P<0.01)。实验终止时分别测血浆硫代巴比土酸反应值浓度,GP 组(0.15±0.016μmol/L)明显低于 NS 组(0.26±0.027μmol/L),P<0.01。结果提示,GP 可有效提高 VFT,可能与 GP 的抗氧化效应及增强心脏耐缺氧能力有关。The effects of gypenosides(GP)on ventricular fibrillation threshold((VFT)and plasma thiobarbituric acid (TBA)value at the end of experiment were studied in electric stimulation induced fibrillation model in rats.GP (50mg/kg iv)significantly increased the VFT from 2.75±0.21 to 6.4±1.49.6.95±1.21,5.7±0.9,4.95±0. 86.4.5±0.7 mA at 15,30.45,60,75 rain after adminstration respectively(P<0.05,or p<0.01 compared with baseline and control group).The plasma TBA value(corrected with time of electric stimulation)in GP group(0.15±0.016μmol/L)was lower than that in control group(0.26±0.027μmol/L,p±0.01).The results suggested that GP could exert a protective effect on ventricular fibrillation,which might relate to its effects of antioxidation and incerase myocardial anti-hypoxic ability.

关 键 词：绞股蓝总皂甙 心室纤颤阈值 硫代巴比土酸反应值 

分 类 号：R285.5[医药卫生—中药学]