丹参对实验性急性胃粘膜损伤的影响  

Effect of Salvia Miltiorrhiza on Acute Gastric Mucosal Damage Induced by Ethanol in Rats

作　　者：黄梅芳[1] 邓长生[1] 陈德基[2] 易秀云 周燕[1] 

机构地区：[1]湖北医科大学第二医院消化内科,武汉430071 [2]湖北医科大学病理教研室

出　　处：《中国中西医结合杂志》1995年第S1期122-123,379,共3页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：用无水乙醇制备大鼠急性胃粘膜损伤模型,丹参水溶液预先给药作为胃粘膜保护剂,观察丹参对乙醇性急性胃粘膜损伤的影响。结果显示丹参组胃粘膜损伤指数(19.46±1.14mm)明显低于乙醇组(71.42±1.23mm),P<0.01。组织学观察结果证实丹参组Ⅱ级和Ⅲ级损伤率明显低于乙醇组(P<0.05,P<0.01)。结果说明丹参对大鼠乙醇性急性胃粘膜损伤有保护作用。两种给药途径比较显示,胃饲优于静脉给药;剂量实验表明,丹参的胃粘膜保护作用呈剂量依赖关系。This study was performed to determine the protective effect of Salviae miltiorrhiza(SM)on acute gastric mucosal damage induced by ethanol in rats.Acute gastric mucosal damage was induced by intragastric ethanol in- stillation.The reaults showed the administration of SM solution before ethanol instillation caused a significant reduction of mucosal damage.Histologic analysis showed SM solution treatment before ethanol challenge reduced Ⅱ and Ⅲ grade damage rate was lower than that in ethanol group.These reaults clearly showed that SM solu- tion orally administered to rats could prevent hemorrhagic necrotic lesions of gastric mucoses induced by ethanol.

关 键 词：乙醇 急性胃粘膜损伤 丹参 

分 类 号：R285.5[医药卫生—中药学]