丹参对实验性肝硬化细胞外基质含量的影响  

Study on Effects of Salvia Miltiorrhiza on Extracellular Matrix Content of Experimental Liver Cirrhosis

作　　者：尹镭[1] 赵元昌[1] 马学惠[1] 龚爱玉[1] 陈贤明[1] 许瑞龄[1] 王蕊[1] 韩德五[1] 

机构地区：[1]山西医学院肝病研究所,太原030001

出　　处：《中国中西医结合杂志》1995年第S1期145-147,383,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：采用复合病因复制肝硬化动物模型,经丹参治疗后,观察肝脏细胞外基质含量的变化。结果表明,丹参可降低血清透明质酸含量;免疫组化经图像分析仪定量测定表明丹参可降低肝内纤维连接蛋白与层连蛋白含量;同时可降低肝内胶原蛋白的含量,使肝纤维化程度明显减轻。The effects of Salvia miltiorrhiza (SM) on extracellular matrix of experimental liver cirrhosis have been studied.The results indicated that SM could decrease the contents of hyaluronic acid in serum.SM also could re- duce the contents of fibronectin and laminin in hepatic tissue,detected by immunohistochemistry and digital im- age analysis.Therefore,the contents of collagen and fibrosis of the liver were markedly alleviated in SM group than that in controls.

关 键 词：肝硬化 透明质酸 纤维连接蛋白 层连蛋白 

分 类 号：R285.5[医药卫生—中药学]