茯苓醇提物对大鼠急、慢性肝损伤的防治  

Study on Preventive and Therapeutic Actions of Poria Extract on Acute and Chronic Hepatic Injury in Rats

作　　者：赵元昌[1] 尹镭[1] 马学惠[1] 韩德五[1] 许瑞龄[1] 陈贤明[1] 王蕊[1] 

机构地区：[1]山西医学院病理生理教研室,太原030001

出　　处：《中国中西医结合杂志》1995年第S1期147-149,383,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：在四氧化碳、高脂低蛋白饮食等复合病因作用下形成大鼠实验性肝硬变,经茯苓醇提物治疗3周,结果表明,药物可减轻实验动物肝纤维增生度,降低肝内胶原蛋白含量,增加尿羟脯氨酸排出(与肝硬变对照组比较,P<0.01),表明茯苓醇提物可促进胶原降解及肝纤维重吸收。结果还显示茯苓醇提物可减轻急性肝损伤动物肝细胞变性、坏死,降低血清谷丙转氨酶活性。The experimental cirrhosis in rats was induced by injection of CCl_4 and dietetic injury.Poria cocos extract ( PE) was given for 3 weeks after cirrhosis was established.The results indicated that PE could alleviate hepatic fibrosis,decrease collagen protein contents of liver,and increase urinary hydroxyproline excretion (compared with cirrhosis controls,P<0.01).It was shown that PE could promote collagenolytic activity and collagen re- sorption in cirrhotic rats.The results also revealed that PE could reduce degeneration and necrosis of hepatic cells and decrease serum glutamic pyruvic transaminase (SOPT) level.

关 键 词：茯苓醇提物 肝硬变 羟脯氨酸 

分 类 号：R285.5[医药卫生—中药学]