补肾密骨液预防大鼠卵巢切除后骨质疏松  

Prevention of Bushen Migu Ye(补肾密骨液)against Osteoporosis in Ovartectomized Rats

作　　者：谢晶[1] 杜靖远[1] 

机构地区：[1]同济医科大学附属协和医院骨科研究室,武汉430022

出　　处：《中国中西医结合杂志》1995年第S1期271-273,399,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：选用7～8月龄雌性 wistar 大鼠,卵巢切除后用补肾密骨液治疗,10周后,取大鼠胫骨近端制成不脱钙骨切片,行骨组织形态计量学测定,并测定禁食尿钙与肌酐比值、尿羟脯氨酸含量、胫骨钙、镁含量及股骨中段骨密度。结果证明,卵巢切除后大鼠小梁骨体积、骨钙、镁含量降低,显示绝经后骨质疏松症动物模型成立。补肾密骨液治疗组各指标优于盐水组,表明该药能抑制过高的骨转换,预防绝经后骨质疏松。In order to study the preventive effect of Bushen Migu Ye(BSMGY)against post menopausal osteoporosis, female Wister rats at 7-8 months old were divided into following groups:sham operation,bilateral ovariectomy (OVX),OVX treated with estradio,OVX treated with BSMGY and OVX treated with normal saline(NS). Ten weeks later,proximal tibiae were processed undecalcifiedly for quantitative bone histomorphometry.The ra- tio of fasting urinary calcium and creatinine,the content of calcium and magnesium in tibiae,bone mineral densi- ty(BMD)were also measured.It was shown that the trabecula cancellous bone volume and the content of calci- um and magnesium in tibiae after OVX were markedly lowered,which revealed that the model of post menopausal osteoporosis were established.The parameters of BSMGY were better than those of NS group and was close to the group of estradiol,which proved BSMGY could suppress the high bone turnover and prevent the occurrence of post menopausal osteoporosis.

关 键 词：补肾密骨液 卵巢切除术 骨质疏松 骨组织形态计量学 

分 类 号：R285.5[医药卫生—中药学]