益脑灵对大、小鼠记忆损害的改善作用  

Effect of Improving Impaired Memory in Rats and Mice by Yi Nao Ling(益脑灵)

作　　者：杜贵友[1] 刘淑芝[1] 王跃生[1] 王秀荣[1] 吕烽[1] 李计萍[1] 费红 宗桂珍[1] 崔海峰[1] 叶文华[1] 赵雍[1] 景厚德 

机构地区：[1]中国中医研究院中药研究所,北京100700

出　　处：《中国中西医结合杂志》1995年第S1期331-334,407,共5页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：用“多用被动回避反射仪”研究了益脑灵翻转氢溴酸东莨菪碱(Scop)和乙醇所致大、小鼠学习记忆获得及再现损害;结果表明,益脑灵15.4g/kg、7.7g/kg 灌胃7天能翻转 Scop 所致大鼠学习获得损害;23.0g/kg、7.7g/kg 可翻转 Scop 所致小鼠学习记忆获得损害(避暗法),并能翻转 Scop 所致小鼠记忆再现损害(跳台法);3.9g/kg 能翻转乙醇所致小鼠记忆再现损害。结果提示益脑灵有改善动物的学习记忆功能。Using the multi-used passive avoidance reflexometer,the effects of Yi Nao Ling (YNL) on turning over the scopolamine (Scop) or ethanol induced impairment of learning and memory retention in rats and mice were exam- ined.The results were as follows:(1) YNL (15.4 g/kg or 7.7 g/kg.i.g.) given 7 days turned over the Scop in- duced impairment of learning gain in rats.(2) With the dose of 23.0 g/kg or 7.7 g/kg,YNL turned over the Stop-induced impairment of learning and memory gain of step-through,and impairment of learning and memory retention of step- down in mice.(3) With the dose of 3.9 g/kg,YNL turned over the ethanol-induced impair- ment of memory retention in mice.These results showed that YNL could improve the learning and memory func- tion in animals.

关 键 词：益脑灵 氢溴酸东莨菪碱 记忆损害 

分 类 号：R285.5[医药卫生—中药学]