胶体次枸橼酸铋对大鼠胃粘膜Na~＋－K~＋－ATP酶的作用  

EFFECT OF CBS ON Na-K-ATPase OF RAT GASTRIC MUCOSA

作　　者：王莉[1] 陈员根[1] 陆玮[1] 

机构地区：[1]上海医科大学华山医院

出　　处：《中华消化杂志》1995年第S1期33-35,共3页Chinese Journal of Digestion

摘　　要：本文观察了大鼠胃粘膜急性损伤前后Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ的变化，以及不同剂量胶体次枸橼酸铋（ＣＢＳ）对无水乙醇所致胃粘膜病变的预防作用和所引起的Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活力的改变。结果表明，大鼠胃粘膜损伤时Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活力下降。ＣＢＳ对无水乙醇所致胃粘膜损害有预防作用，同时刺激胃粘膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活力升高，并呈现量效关系。这些结果表明胃粘膜Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ在胃粘膜抗损害机制中可能发挥重要作用，ＣＢＳ的抗溃疡作用可能与其诱发Ｎａ＋－Ｋ＋－ＡＴＰａｓｅ活力升高有关。The change of Na-K-ATPase activity in gastric mucosa of rat was studied before and after acute gastric injury induced by 100% ethanol,and the effect of CBS administered in-advance was also studied.Our data showed:1.Na-K-ATPase activity decreased significantly when rat gastric mucosa was injured;2.CBS had protective effect on rat gastric mucosa,and increased Na-K-ATPase activity activity at the same time;3.The effect of CBS mentioned above was dose-dependent.These results shows that CBS plays an important role in gastric protective mechanism,its anti-ulcer effect may be connected with the increase of Na-K-ATPase activity of the gastric mucosa.

关 键 词：胃粘膜损伤 NA^+-K^+-ATP酶 胶体次枸橼酸铋 

分 类 号：R965[医药卫生—药理学]