核酸的分子静电势──Ⅳ　自补十二聚合物序列d（Cp　Gp　Cp　Gp　Ap　AP　Tp　Tp　Cp　Gp　CP　G）的分子静电势  

THE MOLECULAR ELECTROSTATIC POTENTIAL OF NUCLEIC ACIDS THE MOLECULAR ELECTROSTATIC POTENTIAL OF B-DNA DODECAMER D(GP GP CP GP AP AP TP TP CP GP CP G)

作　　者：高桂珍[1] 李卫华[1] 刘小阳[1] 曹稳根 刘少民[1] 戴亚[1] 谢跃勤 罗永娟[1] 金闻博[1] 

机构地区：[1]安徽宿州师专,合肥经济技术学院

出　　处：《合肥工业大学学报（自然科学版）》1995年第S1期175-179,共5页Journal of Hefei University of Technology：Natural Science

摘　　要：本文介绍了Ｂ－ＤＮＡ自补十二聚合物序列ｄ（ＣｐＧｐＣｐＯｐＡｐＡｐＴｐＴｐＣｐＯｐＣｐＧ）的分子静电势的计算结果．讨论了这种结构对性能的影响．这些结果与其晶体的性质有关．尤其注意到寡核苷酸（ｏｌｉｇｏｎｕｃｌｅｏｔｉｄｅ）的螺旋中心的静电势比其末端要深．这是如此短的螺旋的一般特性，而与碱基序列无关，但与ＤＮＡ寡聚体的反应性有重要关系．he paper presents the computation results of the electrostatic potential of the B-DNA self-complementary dodecamer CCGAATTCGCG. The crystal structure influences on the caluclated properties are discussed. A particularly significant general finding concerns the greater negative potential in the center of the oligonucleotide helix than at its extremities. This will be a general feature of such short heliees, independant of their base sequence. It may have important implications for the reactivity of DNA oligomers.

关 键 词：B-DNA 十二聚合物序列 分子静电势 

分 类 号：O629.74[理学—有机化学]