根据S—100蛋白阳性胶质细胞的变化判断脑挫伤时间的实验研究  

Experimental Study on Time Estimation of Brian Contusion through S-100 Protein Changes of Positive Glia

作　　者：汪德文[1] 张国华[1] 姜景涛[1] 李如波[1] 陈怀芳[1] 吴旭[1] 刘桂琴[1] 

机构地区：[1]中国医科大学法医病理教研室,中国医科大学第三临床学院内科

出　　处：《法医学杂志》1995年第4期145-146,169+187,共4页Journal of Forensic Medicine

摘　　要：本文米用免疫组织化学ＡＢＣ法，观察了２４只大白鼠脑挫伤不同时间的胶质细胞特异性标志物Ｓ－１００蛋白的变化。结果表明，挫伤２天后Ｓ—１００阳性胶质细胞的胞体开始增大，突起不明显，随着脑挫伤时间的延长，胞体增大，突起明显的Ｓ—１００阳性胶质细胞数量明显增加，到第五天时达高峰，在脑挫伤的周围区均为胞林大、突起明显的Ｓ—１００阳性细胞，此结果表明Ｓ－１００蛋白的变化可用于挫伤后时间的判断。S-100 protein positive glia of 24 contused rats' beam c was observed at different intervals by immunothistochemical ABC method. The results showed that 2 days aftet contusion S-100 protein positive glia was enlarged with no distinct process. With longer duration of the cerebral contusion, the glia was enlarged and increased markedly and peaked at 5 days. The S-100 protein positive enlarged glia were distributed in periphery of contusive area. It is concluded that the S-100 protein can be used to estimate the time of brain contusion.

关 键 词：脑挫伤 免疫组化 S—100蛋白. 

分 类 号：D919[医药卫生—法医学]