SYNTHESIS OF STEREO-ISOMERS OF SECOCLAUSENAMIDEⅠAND SECODEMETHYLCLAUSENAMIDE Ⅱ  

作　　者：Jin Fa DU Jin ZHOU and Liang HUANG(Institutc of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050) 

出　　处：《Chinese Chemical Letters》1994年第4期269-270,共2页中国化学快报（英文版）

摘　　要：D-mannitol through oxidation of its diacetonide gave aldehyde which condensed with PhTi(Oipr)3 stercoselechvely to yield (2R,3R) and (2R,3S) in the ratio of 9: 1. The 1,2-acetonide was transformed to 2,3-aeetonide and then oxidizeg to acid . Amination of followed by hydrolysis gave the expectal amide, 3S,4R Ⅰ and Ⅱ. Their m.p. and [α]differed from those rrported for the natural products whose previously proposedconfigurations were thus reviews.D-mannitol through oxidation of its diacetonide gave aldehyde which condensed with PhTi(Oipr)3 stercoselechvely to yield (2R,3R) and (2R,3S) in the ratio of 9: 1. The 1,2-acetonide was transformed to 2,3-aeetonide and then oxidizeg to acid . Amination of followed by hydrolysis gave the expectal amide, 3S,4R Ⅰ and Ⅱ. Their m.p. and [α]differed from those rrported for the natural products whose previously proposedconfigurations were thus reviews.

分 类 号：O623[理学—有机化学]