病毒性冠状动脉炎导致心肌梗塞的临床与实验观察  

Viral Coronary Arteritis and Myocardial Infarction a Clinical and Experimental Observation

作　　者：陈曙霞[1] 包世宏[1] 梅尚文[1] 章隆泉[1] 姚季生[1] 刘晶星[1] 

机构地区：[1]上海第二医科大学附属仁济医院心内科

出　　处：《上海交通大学学报（医学版）》1994年第S1期16-21,共6页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：为探索青年人心肌梗塞是否由于病毒所引起，作者借助于Ｂａｌｂ／ｃ小鼠心肌炎模型的建立，发现Ｂａｌｂ／ｃ小鼠经腹腔接种柯萨奇Ｂ＿（３ｍ）亲心肌毒株１０００～１００００ＩＤ＿（５０）０．１ｍｌ后９～１０ｄ的心肌切片中除见心肌细胞坏死，间质淋巴细胞浸润等病理变化外，４１．６６％的小鼠心脏可见小血管内皮细胞肿胀。管壁增厚管腔狭窄等病理变化，同时报道了１１例病毒中抗体阳性的青年型心肌梗塞．其中８例作心肌活检发现除心肌细胞坏死间质淋巴细胞浸润外，均有小血管壁的病理变化，并讨论了病毒性冠状动脉炎与心肌梗塞的关系。To investigate the etiology of myocardial infarction in young subjects,we established an animal model of virus myocarditis in Balb/c mice by intraperitoneal injection of CoxB3m 1000～10000 ID_(50) 0.1ml. At 9～10 d post-injection, it was found that the vascular wall became thickened and endothelial cells swollen in the myocardium aside from foci of necrosis and lymphocytic infiltration. Eleven cases of acute myocardial infarction in young adults were reported. Myocardial biopsy was carried out in 8 of the cases. All showed vascular changes,necrotic foci and lynphocytic infiltration almost same as those in the animal model. The relationship between viral coronary arteritis and myocardial infarction was discussed.

关 键 词：心肌梗塞 病毒性心肌炎 柯萨奇B_(3m)病毒 冠状动脉炎 心肌病理学 

分 类 号：R542.220.2[医药卫生—心血管疾病]