硝普钠用于不同程度的控制性降压对犬血流动力学影响的实验研究  

Hemodynamic Effects of Hypotension on Different Levels Induced by SNP in Dogs

作　　者：王明玲[1] 袁世荧[1] 汪尔佳 曾邦雄[1] 

机构地区：[1]同济医科大学附属协和医院麻醉学教研室,武汉430022

出　　处：《华中科技大学学报（医学版）》1994年第S2期109-110,114,共3页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：本实验观察了硝普钠（SNP）使MAP分别下降10％、20％、30％、40％及50％时血流动力学变化，当MAP下降幅度＞30％以上时，HR显著增快，但CI、SVI、LSWI均显著下降。LSWI下降幅度大于PAWP。当MAP下降幅度＞40％以上时，CVP、PAP显著降低，但PAWP、PVR仍下降不显著。硝普钠能扩张肺动脉，这可能对肺动脉高压患者有利。其降压幅度＞30％则可能对心脏功能有抑制作用并可能显著减少回心血量。The hemodynamic effects of deliberate hypotension induced by SNP was investigated．The MAP was controlled to be reduced the by approximately 10％，20％，30％，40％and 50％of the control value.When MAP was reduced by more than 30％ of the control，HR increased markedly，but CIm SVI,LSWI decreased significantly.The decrcase margin of LSWI was large than that of PAWP.When MAP was declined by more than 40％ of the control，CVP，PAP decreased significantly，but PAWP，PVR had no sig nificant changes.The arteria pulmonalia was dilated by SNP，which might be favorable for the patient with pulmonary hypertension． When MAP was decreased to more than 30％ of the control，the cardiac function maybe depressed and the cardiac blood volume was decreased significantly．

关 键 词：硝普钠 控制性降压 血流动力学 

分 类 号：R965[医药卫生—药理学]