大叶牛奶菜孕甾甙成分研究  

Structure Determination of Marsdekoiside G

作　　者：阮金兰[1] 黄友珍[2] 丁惟培[1] 

机构地区：[1]同济医科大学计划生育研究所,武汉430030 [2]同济医科大学基础医学院,武汉430030

出　　处：《华中科技大学学报（医学版）》1994年第S2期179-182,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：世界卫生组织资助课题

摘　　要：用硅胶层析及反相硅胶层析法，从大叶牛奶菜（MarsdeniakoiTsiang）抗生育活性的甲醇提取物中分离获得一孕甾四糖甙。经化学反应，波谱分析，酸碱降解及其水解产物的鉴定，确定其结构为12-0-cvnnamyl-dihydrosarcostin-3-0-β-D-glucopyranosyl（l→4）-0-3-0-methyl-6-deoxy-β-D-allopyranosyl(1→4)-0-β-D-oleandropyranosyl(1→4)-0-β-D-cymaropyranoside,命名为大叶牛奶菜甙庚（marsdekoisideG）。经系统文献检索证明其为首次自该植物中分离得到。A pregnane glycoside was isolated from Marsdenia koi Tsiang by column chromatography.The structure was identified as12-0-cinnamyl-dihydrosarcostin-3-0-β-Dglucopyranosyl（1→4）0-3-0-mehtyl-6-deoxy-β-D-allopyranosyl（1→4）-0-β-D-oleandropyranosyl（1→4）-0-β-D-cymaropyranoside on the basis of IR,UV,1H-NMR,13CNMR and FD-MS.It is isolated from this plant for the first time and named as marsdekoiside G.

关 键 词：大叶牛奶菜 大叶牛奶菜甙庚 化学 药物 

分 类 号：R917[医药卫生—药物分析学]