红霉素对正常人及胆石症患者胆囊收缩功能的影响  

EFFECTS OF ERYTHROMYCIN ON MOTILITY OFGALLBLADDER IN NORMAL AND GALLSTONE SUBJECTS

作　　者：刘福平[1] 王秀敏[1] 韩英[1] 李世荣[1] 张梅[1] 郑力[1] 

机构地区：[1]北京军区总医院

出　　处：《中华消化杂志》1994年第S1期36-38,共3页Chinese Journal of Digestion

摘　　要：通过红霉素对正常人和胆石症患者空腹及餐后胆囊收缩功能影响的观察。发现胆石症Ⅰ、Ⅱ组空腹胆囊体积（ＦＧＶｓ）的显著大于健康组（Ｐ＜０．０５），餐后胆囊排空率（ＰＧＥＲ）显著低于健康组（Ｐ＜０．０１）。口服红霉素５００ｍｇ可明显降低健康组及胆石症Ⅰ组的ＦＧＶｓ，增加ＰＧＥＲ。胆石症Ⅱ组口服红霉素５００ｍｇ加阿托品０．６ｍｇ后ＦＧＶｓ和ＰＧＥＲ无变化。提示红霉素促胆囊收缩效应与胆碱能途径有关。口服红霉素可降低ＦＧＶｓ，纠正胆石症患者餐后胆囊排空障碍。The stimnulation of gallbladder contraction,measured by ultrasound,in both normal subjects and those with gallstones by erythromycin-a motilin receptor agonist was studied. Fasting gallbladder volumes (FGVs) in both gallstone group Ⅰ and Ⅱ were markedly larger than those in normal group(P<0.05). Postprandial gallbadder emptying rate(PGER) in two gallstone groups was lower than that of normal group(P<0.01). Oral erythromycin (500mg; vs. placeb) significantly reduced FGVs,and increased PGER both in normal group and gallstone group Ⅰ. In gallstone group Ⅱ, oral erythromycin (500mg) plus atropine (0.6mg) changed neither FGVs nor PGER' These results suggest that the change of gallbladder contraction casused by erythromycin through stimnulating motilin receptor seems bo be mediated via cholinergic pathways. Oral erythromycin can significantly reduce FGVs and correct the postprandial gallbladder motility defect in a proportion of patients with gallstones.

关 键 词：红霉素 胆囊收缩功能 胆石症 

分 类 号：R969[医药卫生—药理学]