脾气虚泄泻患者与非脾气虚泄泻患者胃动素和PGE_2含量的比较  

Compare Motilin and Prostaglandin E_2 Concentration between Patients of Chronic Diarrhea with and without Spleen-Deficiency

作　　者：任平[1] 宋国增[1] 夏天[2] 黄熙[2] 张忠兵[2] 孙安华[2] 李彩宁[2] 胡家露[2] 

机构地区：[1]第四军医大学唐都医院,西安710038 [2]第四军医大学西京医院

出　　处：《中国中西医结合杂志》1994年第S1期21-23,417,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(38809281)

摘　　要：用放射免疫分析法对比观察了54例脾气虚泄泻患者,53例非脾气虚泄泻患者(湿热内盛22例、肝气郁结18例及脾肾阳虚13例)和57例无泄泻且无脾气虚的对照者血浆和十二指肠降段胃动素(MOT)、降结肠和直肠的 PGE_2含量。发现脾气虚泄泻患者十二指肠降段胃动素含量明显低于对照组和3组非脾气虚泄泻患者,降结肠和直肠 PGE_2含量却明显高于对照组和非脾气虚泄泻组;非脾气虚泄泻组中各型之间胃动素和 PGE_2的含量均无明显差异。提示脾气虚泄泻患者胃动素含量下降、PGE_2含量增高可能是脾失健运的实质之一。By means of radioimmunoassay,the motilin and prostaglandin E_2(PGE_2)concentration in plasma and intestinal mucosa of chronic diarrhea(CD)patients with and without Spleen-Deficiency(SD)were determined respectively.Results:(1).Descending duodenal mucosal concentration of motilin in CD-SD patients was significantly decreased when compared with that in controls without SD or CD only.the motilin in latter increased predominantly.(2)The elevated PGE_2 concentration in descending colonic and rectal mucosa in both diarrhea patients with and without SD were demonstrated respectively.but the PGE_2 concentration in the patients of SD was significantly higher than that witlaout SD.The results suggested that the reduced concentration of motilin and the elevated concentration of PGE_2 in SD patients might he one of essence of SD and reduce motilin concentration could be regard as a specific objective and quantitative index of SD.

关 键 词：脾气虚 慢性泄泻 胃动素 前列腺素 E₂ 

分 类 号：R256.3[医药卫生—中医内科学]