胃寒证、胃热证与胃液中PGE_2、6-keto-PGF_(1α)的关系及其机理的探讨  

Study on Mechanism and Relationship between PGE_2 PGF_(1a) of Gastric Juice and Stomach Cold and Heat Syndrome

作　　者：许自诚[1] 傅关孺 

机构地区：[1]兰州医学院第一附属医院,兰州730000 [2]安徽省广德县人民医院

出　　处：《中国中西医结合杂志》1994年第S1期76-78,426,共4页Chinese Journal of Integrated Traditional and Western Medicine

摘　　要：本文报告了用放射免疫法测定了慢性胃病两组患者胃液中 PGE_2和6-keto-PGF_(1α)的含量。结果:胃热组 PGE_2的含量明显高于胃寒组,两组间有显著性差异(P<0.05).但胃寒组与对照组相比,无显著性差异(P>0.05)。6-keto-PGF_(1α)的含量,各组间相比,则无显著性差异(P>0.05)。提示胃寒证、胃热主发病的主要机理,可能与胃液中前列腺素的种类和含量的多寡有密切的关系.其中主要是 PGE_2。胃寒证、胃热证是一种较低水平的寒热表现。The level of PGE_2 and PGF_(1α) in the gastric juice was determined by RIA.The results showed that there was a higher level of PGE_2 and a lower level of PGF_(1α) in the Stomach Heat Syndrome group,while a lower level for PGE_2 and a higher level of PGF_(1α) in the Stomach Cold Syndrome.There was significant difference between the two groups(P<0.05).The results indicated that there was a close relationship between the levels and kinds of prostaglandins of gastric juice and the kinds of Stomach Cold and Heat Syndromes in TCM.PGE_2 was possibly playing an essential role in the pathogenesis of Stomach Heat Syndrome,meanwhile PGF_(1α) was also important in the pathogenesis of Stomach Cold Syndrome.This pathogenesis was realized through the sympathetic adrenomedullary system.The Stomach Heat and Cold Syndromes were a relatively lower level for manifestation of Heat and Cold.

关 键 词：胃寒证 胃热证 前列腺素 E₂ 6-酮-前列腺素 

分 类 号：R256.3[医药卫生—中医内科学]