胰岛素、舒血管前列腺素与高血压及Ⅱ型糖尿病  

Serum Insulin and Prostaglandins in the Patients with Hypertension and Type Ⅱ Diabetic Mellitus

作　　者：贾伟平[1] 丁汉伦[1] 戴信刚[1] 毛共存 程秦娣[1] 倪红燕 袁晓红 

机构地区：[1]西安医科大学第二附属医院内分泌科

出　　处：《中华高血压杂志》1994年第3期167-169,共3页Chinese Journal of Hypertension

摘　　要：对15例高血压、20例Ⅱ型糖尿病、15例正常人进行口服葡萄糖耐量试验和胰岛素释放试验（IRT），同时测定6-酮-前列腺素F1c（6－Keto－PGF1a）和前列腺素E2（PGE2）。高血压组基础和糖刺激后血清胰岛素水平显著升高（P＜0．001）而6－Keto－PGE1c水平显著下降（P＜0．001）。各组胰岛素水平和6－Keto－POF1a显著负相关（r=0．57，P＜0．05）．结果表明高血压、Ⅱ型糖尿病存在高胰岛素血症和低舒血管前列腺素血症，这些改变可能是高血压发病机制之一。This stody is to test the hypothesis that hyperinsuline-mia resulted in hypepension is in relation to the low leveis of vasodi-lation prostaglandins in the they. Tht serum iusulin and plasma 6-Keto-PGF1, PGE2 were measured in 15 petients with hypertension, 20petients with normobeive NIDDM and 15 normal controls. Thefasting the challenging serum insulin levels wcre markedly increased (P<0. 01) while the Plasma 6-Keto-PGF1 and PGE2 were signifi-cantly reduced (P < 0. 01) during oral glucere tolerance test(OGTT) in the hypertensive petients. The plasma 6-Keto-PGF1 wasstrongly inverse correlated (r= - 0. 57, P< 0.05) to thc elevated in-sulin in tthe groupe. The results suggest that the changes in insulinand prostaglandins may play role in the incrase in blood pressure inpetients with hypertension.

关 键 词：胰岛素 前列腺素 高血压 Ⅱ型糖尿病 

分 类 号：R544.1[医药卫生—心血管疾病]